Organic osmolyte betaine mitigates the deleterious effects of Diclofenac in vivo in wistar albino rats

Diclofenac sodium (DF) is a non-steroidal anti-inflammatory drug (NSAID) that possesses antipyretic, analgesic, antinociceptive and activities. Like other NSAIDs, DF known to be associated with renal, cardiovascular, gastrointestinal complications. The present study was carried out evaluate the adverse effects of in vivo wistar albino rats assess if oral administration organic osmolyte betaine mitigates effect DF. Eighteen male Wistar were divided into three groups, one group animals fed orally 20 mg/kg once/day, received combination 30 betaine, once/day. Apart from hematological biochemical parameters, histopathological changes liver, lungs, brain, heart kidney also investigated. Histopathological alterations found kidney, lungs DF-treated minimal or absent + betaine-treated animals, as compared untreated control. results showed treatment.